reverse transcription

noun

: the process of synthesizing DNA using RNA as a template and reverse transcriptase as a catalyst

Examples of reverse transcription in a Sentence

Recent Examples on the Web
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Common testing methods include reverse transcription polymerase chain reaction, viral culture and immunofluorescence assays. Sacbee.com, 23 Jan. 2026 To sequence the genetic material, the Pandemic Response Lab first converts the RNA into DNA, a process known as reverse transcription. New York Times, 17 Aug. 2022 Following reverse transcription–polymerase chain reaction (RT-PCR) testing and genomic sequencing of the samples, each family member was found to be infected by the Omicron variant of COVID-19. Ashley Abramson, Health.com, 29 Dec. 2021 Most tests available today to see if people have the virus are conducted using reverse transcription polymerase chain reaction (RT-PCR) technology. IEEE Spectrum, 29 May 2020

Word History

First Known Use

1971, in the meaning defined above

Time Traveler
The first known use of reverse transcription was in 1971

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Cite this Entry

“Reverse transcription.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/reverse%20transcription. Accessed 30 Jun. 2026.

Medical Definition

reverse transcription

noun
: the process of synthesizing DNA using RNA as a template and reverse transcriptase as a catalyst
reverse-transcribe transitive verb
reverse transcribed; reverse transcribing
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